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OncoPath 0.0.32 (2025-10-09)

Documentation Improvements

README.Rmd

  • NEW: Created comprehensive README.Rmd with detailed module description
  • Enhanced feature descriptions with emojis for better readability
  • Added detailed installation instructions (3 methods)
  • Included quick start examples for both swimmer and waterfall plots
  • Added comprehensive use cases section (Clinical Research, Pathology Research, Publication Support)
  • Expanded acknowledgements section with gratitude to package developers
  • Integrated with ClinicoPath ecosystem documentation

Documentation Website

  • All documentation now available at: https://www.serdarbalci.com/OncoPath/
  • Direct links to swimmer plot and waterfall plot guides
  • Clear integration with main ClinicoPath documentation hub

Vignette Additions

  • NEW: Added 9 comprehensive vignettes for enhanced documentation
  • Clinical Heatmap: clinicalheatmap_comprehensive.Rmd - Clinical heatmap visualization
  • Digital Pathology Suite (4 files):
    • digital_pathology_chatgpt.md - AI-generated pathology analysis guide
    • digital_pathology_claude.md - Comprehensive digital pathology documentation
    • digital_pathology_gemini.md - Alternative AI perspective on digital pathology
    • digital-pathology-analysis-suite.md - Complete digital pathology analysis overview
  • Texture Analysis: HARALICK_TESTING_GUIDE.md - Haralick texture feature analysis testing
  • Agreement Analysis (3 files):
    • COMBINED_USUBUTUN_GUIDE.md - Combined Usubutun plot guide
    • USUBUTUN_ENHANCED_TEST_GUIDE.md - Enhanced testing procedures
    • USUBUTUN_TEST_GUIDE.md - Standard testing guide for agreement visualization
  • Oncoplot: ggoncoplot_documentation.md - Genomic alteration visualization documentation

Function Documentation

  • Added waterfall plot legacy documentation: 09-waterfall-legacy.Rmd
  • Function-specific vignette: 06-function-waterfall.Rmd - Detailed waterfall function guide

Features Summary

Patient Follow-Up Plots

  • 🏊‍♂️ Swimmer Plot Analysis: Timeline visualization with ggswim integration
  • 🌊 Waterfall Plot Analysis: RECIST criteria treatment response analysis
  • Complete support for clinical trial reporting and oncological research

Pathology Analysis Tools

  • 🔬 IHC Heterogeneity Analysis: Immunohistochemistry marker analysis
  • 📊 Diagnostic Test Meta-Analysis: Bivariate meta-analysis with HSROC

OncoPath 0.0.31.84 (2025-10-03)

Major New Features

Diagnostic Test Meta-Analysis for Pathology

  • NEW: Comprehensive diagnostic test accuracy meta-analysis module
  • Bivariate random-effects meta-analysis using the Reitsma method
  • Hierarchical Summary ROC (HSROC) curve analysis
  • Meta-regression capabilities for exploring heterogeneity
  • Publication bias assessment with funnel plots
  • Support for multiple estimation methods (REML, ML, Fixed Effects, etc.)
  • Forest plots for sensitivity and specificity
  • SROC plots with confidence regions
  • Designed specifically for:
    • AI/ML algorithm validation in pathology
    • Biomarker diagnostic accuracy synthesis
    • Systematic reviews of diagnostic tests

IHC Heterogeneity Analysis

  • NEW: Statistical analysis of immunohistochemistry marker heterogeneity
  • Multi-marker evaluation capabilities
  • Robust statistical methods for heterogeneity assessment
  • Specialized tools for pathology biomarker research

Enhancements

Treatment Response Analysis (Waterfall Plot)

  • Improved RECIST criteria implementation
  • Enhanced visualization options
  • Better handling of longitudinal data

Swimmer Plot

  • Continued integration improvements with ggswim package
  • Enhanced data validation
  • Better error handling and user feedback

Dependencies

New Package Dependencies

  • mada: Meta-analysis of diagnostic accuracy studies
  • metafor: Advanced meta-analysis and meta-regression
  • pROC: ROC curve analysis
  • survival & survminer: Survival analysis support
  • boot: Bootstrap methods
  • dcurves: Decision curve analysis
  • Hmisc: Statistical utilities
  • rms: Regression modeling strategies
  • timeROC: Time-dependent ROC curves
  • tidyr: Data tidying operations

Bug Fixes

  • Fixed menu organization for diagnostic meta-analysis
  • Improved variable name handling with special characters
  • Enhanced error messages and user guidance

Internal Changes

  • Updated NAMESPACE with new imports
  • Reorganized menu structure for better discoverability
  • Added comprehensive validation for meta-analysis inputs
  • Improved handling of zero cells in diagnostic data

OncoPath 0.0.31.69 (Previous Version)

Features

  • Swimmer Plot Analysis with ggswim integration
  • Waterfall Plot Analysis with RECIST criteria
  • Treatment Response Visualization
  • Patient Timeline Tracking

Initial Release Features

  • Comprehensive patient follow-up visualization tools
  • RECIST criteria analysis
  • Clinical event tracking
  • Publication-ready visualizations